METHRON® P-314   Polacrilin Potassium

Methron is a high purity pharmaceutical grade weak acid cation exchange resin, potassium form as a free flowing powder. It is suitable for use in the pharmaceutical applications such as taste masking and tablet disintegration. Polacrilin Potassium is derived from crosslinked polymethacrylic acid. Polacrilin Potassium conforms to the specification of monograph for polacrilin potassium in USP/NF.

Characteristics:

Appearance: White to pale cream powder
Matrix: Copolymer of methacrylic acid and divinyl benzene
Functional Group: Carboxylic acid
Ionic form as supplied: Potassium
Solubility: Insoluble in water and in common solvents


Specifications:



READY TO USE GRADES polacrilin potassium USP/NF:

Ready to use grades are drug specific taste masking system enables formulator a single step process. It contains taste masking polymer, sweetener, suspending agent, preservatives, color, flavor and other desire excipients. It is available in various flavors like Banana, Pineapple, Cherry, Strawberry, Peppermint flavor etc. and also as per customer's requirement.

 

As Disintegrating agent: Methron (Polacrilin Potassium) has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without the formation of lumps and thus acts as an effective tablet super disintegrant. It can be used during mixing and/or at lubrication stage.
Ex.: Immediate release tablets, Herbal tablets, Mouth dissolving tablets etc.

As Dissolution Improver: Polacrilin Potassium breaks the tablets into very smaller particles, thus it increases the effective surface area for the absorption of the active substances and thus it increases the dissolution and bioavailability of the active substances.

Examples for Polacrilin Potassium: Cefuroxime Axetil, Cefpodoxime Proxetil, Atorvastatin Calcium, Telmisartan, Glimepiride, Gliclazide, Ondansetron etc.

Examples for Polacrilin Potassium: Ciprofloxacin HCl, Levofloxacin HCl, Fexofenadine HCl etc.